Alexander the Great
Alexander the Great in a few short years ruled a very large empire.
He came to the throne in 336 BC and died thirteen years later in Babylon at the age of 32 in 323 BC
Alexander imported of Greek colonists and culture to the East which is still seen in these countries to this day.
After his death it was split into four regions.
Alexander the Great the Greek that ruled a very big empire.
See Daniel 7 The Bear and Daniel 8 the He Goat with a single horn.
Check out Daniel 11 and what it says about the 400 year period.